Neomycin and Polymyxin B Sulfates and Gramicidin Ophthalmic Solution, USP is contraindicated in individuals who have shown hypersensitivity to any of the components. (Please see full prescribing information for additional precautions.)

Indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis. Warnings: NOT FOR INJECTION INTO THE EYE. Neomycin and Polymyxin B Sulfates and Gramicidin Ophthalmic Solution, USP should never be directly introduced into the anterior chamber of the eye or injected subconjunctivally.

Topical antibiotics, particularly neomycin sulfate, may cause cutaneous sensitization. A precise incidence of hypersensitivity reactions (primarily skin rash) due to topical antibiotics is not known. The manifestations of sensitization to topical antibiotics are usually itching, reddening, and edema of the conjunctiva and eyelid. A sensitization reaction may manifest simply as a failure to heal. During long-term use of topical antibiotic products, periodic examination for such signs is advisable, and the patient should be told to discontinue the product if they are observed. Symptoms usually subside quickly on withdrawing the medication. Application of products containing these ingredients should be avoided for the patient thereafter (see PRECAUTIONS:General).

 For additional information, please see prescribing info link below.